In 2014, Rochester's Shawn Dunwoody created a mural on the Interstate 490 bridge over West Main Street. It depicts the abolitionist Frederick Douglass, as well as Susan B. Anthony, Nathaniel Rochester and Austin Steward - all famous Rochester figures

In 2008, muralist K. Fitch painted a mural of Frederick Douglass in the abolitionist's former home town of Rochester, New York. The mural depicts Douglass in the later years of his life. It had been destoyed by 2014.

In 1959 the Hungarian-American illustrator and muralist Hugo Gellert created the series Seward Park Housing Murals. The four-panel mural series depicts Thomas Jefferson, Abraham Lincoln, Franklin D. Roosevelt and Albert Einstein and was commissioned by the International Ladies Garment Workers Union. The Abraham Lincoln panel has an abolitionist section that features Frederick Douglass, John Brown, Harriet Tubman, Sojourner Truth and William Lloyd Garrison.The mural was threatened with destruction many times, including in 1996 when the building residents voted to become a private co-op. Individuals on the co-op board then voted to rid the lobby of the murals that they deemed racist, ugly, socialist or 'past their time.' But the building manager, Frank Durant, insisted on their preservation.

An unknown artist painted this mural in Harlem, New York City, on the facade of Dining Heritage. It depicts the abolitionists Frederick Douglass and Harriet Tubman, as well as Martin Luther King Jr., Rosa Parks, Jesse Jackson and Malcolm X. It was destroyed in 2015.

This mural was painted in the Bronx, New York City by an unnamed artist and depicts Frederick Douglass in the later years of his life, and the phrase "Education is the pathway to freedom." it had been destroyed by 2016.

Picturing Our Dreams is by incarcerated youth at the Monroe Correctional Facility in Rochester, New York. The mural was created in collaboration with a New York State Library Centre writer, visual artist and Rochester School District teachers. The ideology behind the mural was that inmates could communicate the idea that there is freedom and knowledge inside the jail system. In the centre of the mural, a heart with many key-holes floats around the corresponding keys, and above are the faces of the abolitionists Harriet Tubman and Frederick Douglass, as well as Barack Obama and Dr. Martin Luther King Jr.

As part of a Rochester WALL\THERAPY mural project in 2013, muralist Lunar New Year used Trayvon Martin, a young Frederick Douglass, and a local resident called Christopher to depict three possible paths of African American manhood in his mural I Am/Yo Soy. The young boy on the edge of the mural pleads to the North Star in the sky in a position that echoes Josiah Wedgwood’s famous 18th-century "Am I Not a Man and a Brother" medallion. An older version of Douglass then sits on the right side on the mural, as the only figure beyond the real and painted chain link fences.Lunar New Year, who is an Ecuadorian American Newark-based artist, explained that the mural is about “the history of institutionalized injustice in the USA… Injustice forged Frederick Douglass’s character, robbed Trayvon Martin of his life and [it] is up to us, to dictate what future awaits for young 7 year old Christopher from Rochester.”

In 1988, Mike Alewitz designed and began to direct the creation of Pathfinder Mural in New York City’s West Village. The mural, measuring 79 x 85 feet, was an international collaboration of 80 artists from 20 different countries including Argentina, Canada, Iran, New Zealand, Nicaragua and South Africa. At its dedication, it was hailed as one of the largest political murals in the world. In 1987, Alewitz had approached the leaders of the Socialist Workers Party (SWP), of which he was a member, and proposed that Pathfinder Press sponsored a mural for its Charles Street building. The party approved both the project and his concept of the mural: a celebration of the revolutionary struggles in Cuba, Grenada, Nicaragua and South Africa, as well as in America. The central image of the mural is a large red printing press. The faces of Fidel Castro, Che Guevara, Malcolm X, Karl Marx, and Nelson Mandela loop around it. The abolitionists Frederick Douglass, Harriet Tubman and Sojourner Truth also feature. During the creation of Pathfinder Mural, the National Endowment for the Arts withdrew funding from several controversial projects, prompting a debate on free speech and censorship. For the first few months of this mural's creation, work continued without incident. But in 1989, Patrick Buchanan, a conservative commentator, vilified the mural in the Washington Times, calling it a “six-story shrine to communism, a Marxist Mount Rushmore in Greenwich Village." As the mural neared completion, the dialogue between Alewitz and the SWP started to break down. Alewitz was blocked from attending the mural dedication ceremony on November 19, 1989. During December, vandals threw glass bottles filled with white paint at the mural. In 1996, the mural was removed in order to repair cracks in exterior wall of the Pathfinder building, and by 2003, the building on which Pathfinder Mural was housed was sold for around $20 million.

This mural, part of a wider series called La Lucha Continua/The Struggle Continues, is split into two halves. The bottom half shows anonymous arms merchants in suits, and the top portrait shows portraits of local residents alongside the leaders Nelson Mandela, Daniel Ortega, Robert F. Williams and the abolitionist Harriet Tubman, among others.

In 2012, Mexican muralist Luis Zarate created the mural Underground Railroad on Bay Street in Sodus Point, Wayne County in upstate New York. Sponsored by the Neighborhood Association of Sodus Point, the mural depicts the involvement of Sodus Point in the Underground Railroad of the 1850s. Captain George Garlock, who captained the ship Free Trader out of Sodus Point and picked up runaway slaves on his way to Canada, is depicted in the centre of the mural on the boat between the black antislavery leaders Harriet Tubman and Frederick Douglass. On July 14, 2012, a dedication ceremony revealed a plaque was mounted below the mural that reads: “This mural depicts a scene of the Underground Railroad. From stories passed down there were several safe houses in this area that were used to harbor 'Freedom Seekers.' These included the old Cohn Farm and the old Sodus Fruit Farm and what is now Maxwell Creek B & B and Silver Waters B & B. Sometimes a schooner, out of the old Sodus Point ore dock, would pick up slaves on its way to Canada."

In 2005, Artmakers Inc. created a large-scale political mural titled When Women Pursue Justice. During the genesis of the mural, it seemed like an overly ambitious project with little funding, and a heavy reliance on the generosity of its collaborators. Located in Brooklyn, at the busy intersection between Nostrand and Greene Avenue, the mural is populated with women who worked towards justice and social change over the last 150 years. The most visually noticeable figure on the mural is the thirty-five-foot image of Shirley Chisholm astride a golden horse and dressed in armour of African mud and kente cloth.  Surrounding Chisholm are 90 women who risked their lives and liberty to achieve voting rights, civil rights, racial justice, health and reproductive rights, and environmental justice and protection – including the abolitionists Harriet Tubman and Sojourner Truth, as well as Angela Davis, Wilma Mankiller, Margaret Sanger, and Dorothy Day.

In 1999, artist Christopher Wynter created a mosaic installation at the Cathedral Parkway subway station in Harlem. He explained that the 3-part mosaic series titled Migrations “present the ideas of uprooting, migration, and progress in symbolic form." The installation features Frederick Douglass and was placed in the subway station that runs underneath Frederick Douglass Boulevard.

Two years prior to the Texas Centennial Exposition, Aaron Douglas created a four-part mural series titled Aspects of Negro Life, to be housed in the 135th Street branch of the New York Public Library, the Schomburg Center. The various panels portray black history from slavery through to present. The various panels are titled, The Negro in an African Setting, From Slavery Through Reconstruction, Song of the Towers, and An Idyll of the Deep South, and depict the breaking of chains, the idea of self-emancipation, liberation, and the celebration of African culture.    

In 1973, Cityarts Workshop muralist James Jannuzzi painted a mural in New York City about Puerto Rican abolition, gang culture and black heritage. The mural includes a shirtless, muscular figure playing drums in a tropical landscape, Nubian symbols such as the ankh next to pyramids, and Ramón Emeterio Betances – an abolitionist and the father of the Puerto Rican independence movement. In the centre of the mural, Jannuzzi painted seven spears, acknowledging the presence of the neighbourhood’s seven gangs through the use of colour. By 1978, the mural had already started to deteriorate. Wanting to use the mural as a background in a film, a production company sought out Jannuzzi, asking him to retouch sections of the mural. Having hung up his paintbrush already, Jannuzzi directed the production company to Cityarts' Alfredo “Freddy” Hernandez who retouched the mural with a Dancing Madonna. By 1995 all that remained of Afro Latin Coalition was the Dancing Madonna in her red and white dress, and by 2000, the entire mural has disappeared.

In 1990, this mural titled Nation of Islam at Charles Place in Brooklyn was created. The mural unites many radical figures of black history, including the antislavery leader Frederick Douglass, W.E.B. Du Bois, Elijah Muhammad, H. Rap Brown, Malcolm X, Marcus Garvey, Eldridge Cleaver and Bobby Seale. It has now been destroyed.  

This mural was created in 2008 by an unknown artist. Painted on a storefront on Ralph Avenue in Brooklyn, it depicted Harriet Tubman, Frederick Douglass and Nelson Mandela. As of 2014, it no longer existed.

In 2001, Brooklyn-based muralist Leola Bermanzohn created a mural in the Flatbush area of Brooklyn titled Women Warriors. Bermanzohn works as a muralist for the Groundswell organisation, launched in 1996 with the mission of bringing together artists, youth and community organisations to create murals that beautify local neighbourhoods and give expression to underrepresented ideas and perspectives. Women Warriors was created in collaboration with Sister Outsider – an organisation run by and for women of colour that aimed to help women enter the professional world of work and operate in the political realm. The mural was at the organisation’s headquarters and depicted antislavery leaders Harriet Tubman and Sojourner Truth as well as Nefertiti, Rosa Parks and Assata Shakur, alongside a poem written by Audre Lorde. It had been destroyed by 2015.

In 2011, the Puffin Foundation commissioned Mike Alewitz to paint a mural for the Puffin Gallery of Social Activism that would be on display in the Museum of the City of New York. Completed in 2014, the mural is a tribute to the labour and social justice movements and contains four panels. It includes slave ships and depicts the antislavery leader Frederick Douglass, as well as Martin Luther King Jr., Coretta Scott King and Elizabeth Gurley Flynn.However after viewing the mural, the museum declined to display it. They requested changes that reduced the prominence of Martin Luther King Jr. and added the Women’s Christian Temperance Union.  Alewitz calls this a case of censorship and continues to campaign for his mural to be displayed.

In 1933, the Mexican muralist Diego Rivera painted a 21-panel mural titled Portraits of America. Created for New York City’s New Workers School, the mural focused on issues of racial inequality and depicted the antislavery figures Frederick Douglass and John Brown, as well as shackled slaves - seen here in panel five of the mural. Rivera believed art was a weapon in the class struggle and frequently produced murals about revolution. Rivera, David Alfaro Siqueiros and José Clemente Orozco were the pioneers of the Mexican mural movement, and influenced mid-century African American muralists Hale Woodruff, John Biggers and Charles White. 

Mary Patten painted Douglass Street Mural – Cityarts Workshop’s first Brooklyn-based project – in 1976. Over a five-month period, Patten led a group of 20 teens and adults to develop various themes for the mural that would be located on Douglass Street in the Park Slope area of Brooklyn - an area more commercial than residential at the time. Community meetings and bilingual flyers filled the neighbourhood in the hope of garnering community input and consensus over the choice of imagery.  The three-storey mural takes advantage of the building's structure by presenting the image as book pages waiting to be read. The dystopian nightmare to the right-hand side of the mural attempts to encroach on the multicultural utopian melting pot to the left, only to be fended off by workers and important figures from U.S. history. Folded into the Puerto Rican flag and the red, white and green banner of the African National Congress, are the images of Harriet Tubman, pointing towards the nightmare-scape, alongside Frederick Douglass, Lolita Lebrón, Malcolm X and H. Rap Brown. Under the imperialist eagle and puppet-like figure in its talons, Patten depicts a recent firebombing that had destroyed the homes of several Black families a few blocks away. Speaking of the large rainbow in the image, the muralist incorporated it to show "what is possible when people work and fight together to create what we need: a community school that provides quality education; people sharing skills and tools; dancing together; making music and painting a mural."The mural sought to convey hope and determination in the face of oppression. But by the 1980s, the mural had become obscured by new housing developments.