The world's oldest human rights organisation, Anti-Slavery International, led several initiatives in response to the bicentenary. The Fight for Freedom 1807-2007 Campaign, launched in 2005, called for measures to address the continuing legacies of the slave trade. The publication '1807-2007: Over 200 years of campaigning against slavery' looked back at the work of Anti-Slavery International and its predecessor organisations. The Spotlight on Slavery series of exhibitions and events included debates, lectures, film screenings and photography exhibitions. Anti-Slavery International also collaborated with a number of other organisations and projects in 2007, including Rendezvous of Victory and Set All Free, and contributed exhibition material to various exhibitions around the UK, including the Remembering Slavery exhibition at the Discovery Museum in Newcastle.

In the Recovered Histories online resource, Anti-Slavery International digitised and made accessible for the first time a collection of over 800 pamphlets dating from the 18th and 19th centuries relating to the transatlantic slave trade. The resource captured the narratives of the enslaved, the enslavers, slave ship surgeons, abolitionists, parliamentarians, clergy, planters and rebels. An accompanying touring historical exhibition and an education pack featured testimonies and pictures from Africans subjected to slavery, those participating in the enslavement and those who fought against it. An outreach and resources programme included a series of free regional seminars in April and May 2008, which encouraged dialogue about the transatlantic slave trade and its legacies by bringing together a wide range of groups and organisations who worked on these issues. The workshops were held in Bristol, Edinburgh, Leeds, London and Manchester. A series of short stories were published, inspired by the Recovered Histories resource.

The main aim of the 2007 Bicentenary Cross-Community Forum (2007BCCF) was to facilitate space for dialogue and alliance building in areas of work connected to the legacies of enslavement, related global injustices today and contemporary forms of slavery. The forum was jointly convened by Rendezvous of Victory, Anti-Slavery International and the World Development Movement. The education initiative aimed to assist in discussion and alliance-building on issues arising from the legacies of African Enslavement such as Maangamizi (Afrikan Holocaust) Awareness, Afriphobia, reparations, global injustices today and contemporary forms of enslavement. Open meetings were held in London between 2005 and 2007, and the group produced the 2007 Cross-community e-bulletin three times a year, including comment pieces about the significance of 2007. Task Action Groups were set up, such as the Cross-Community Dialogue Action Group on Education (CCODAGE), jointly hosted by the Council for Education in World Citizenship and the School of Education at Kingston University. A Global Justice Forum was developed out of the 2007BCCF in order to advance work beyond 2007.

This photographic exhibition focused on human trafficking was produced by a partnership of Panos Pictures, Anti-Slavery International, Amnesty International, Eaves and UNICEF. Photographer Karen Robinson’s portraits and tales of women trafficked into prostitution explore the devastating impact on their lives. Also on display were David Rose's panoramic photographs of the ordinary British streets where the stories of modern-day slavery have been played out. The photographs were mounted on a cage-like structure which was specially designed for the exhibition at St Paul's Cathedral. The exhibition was also shown in Edinburgh, Hull and Warsaw, and in 2008, in York.